Myeloproliferative Neoplasms

What are myeloproliferative neoplasms?

Myeloproliferative neoplasms (MPNs) are a group of blood cancers characterised by an overproduction of cells in the myeloid line of development which include certain types of white cell, red cells and platelets.

What are the types of myeloproliferative neoplasms?

According to the World Health Organization classification of myeloid neoplasms, depending on the type of blood cells overproduced, there are 4 common types of MPNs. They are:

  1. Chronic myeloid leukemia (CML): In which there is predominantly an overproduction of granulacytes ( certain types of white cells with granules in them) and their precursors.
  2. Polycythema vera (PV): In which there is predominantly an overproduction of red cells.
  3. Essential thrombocythemia (ET): In which there is predominantly an overproduction of red cells.
  4. Primary myelofibrosis (PMF): In which there is predominantly an overproduction of fibers in the bone marrow.

How do MPNs develop?